Patient-derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunedeficient or humanized mouse. PDX models simulate human tumor biology allowing for natural cancer progression, and offer the most translational research model for evaluating efficacy.

We conducted a comprehensive analysis of genomic alterations in a cohort of PDX samples from 536 PDX models taken from 25 cancer types. Whole-exome sequencing (WES) and RNA-seq data for human and PDX samples were collected from multiple centers (see chart).

The table at right shows the numbers of PDX models studied by cancer type. Click the links to view lists of models, samples, and somatic variants.